从临床样本中分离的扩展光谱β-lactamase产生格拉姆阴性细菌的抗微生物敏感性模式:一个横截面的医院研究
Archana1, Mukesh Kumar1, Shyam Kishor Kumar2
1Department of Microbiology, Netaji Subhas Medical College and Hospital, Bihta, Patna, India.
Journal of family medicine and primary care
|December 17, 2025
概括
这项研究发现,印度比哈尔州27%的扩展光谱β-乳糖酶 (ESBL) 产生格拉姆阴性细菌. 大肠杆菌是发现的最常见的ESBL产生的有机体,突出显著的公共卫生问题.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 格拉姆阴性细菌导致许多疾病.
- 扩展光谱β-乳酸酶 (ESBLs) 有助于细菌的抗微生物药物耐药性.
- 产生的ESBL是一种日益严重的全球健康问题.
研究的目的:
- 为了确定ESBL产生格拉姆阴性细菌的流行率.
- 在临床样本中识别常见的ESBL产生病原体.
- 评估东印度比哈尔州ESBLs的负担.
主要方法:
- 在印度比哈尔州进行的前性横截面研究.
- 包括2022年7月至2024年3月的临床样本 (尿液,,唾液,血液).
- 现型查和ESBL确认的组合磁盘方法.
主要成果:
- 在1123个分离物中,有758个是阴性细菌.
- 27% (208/758) 的克拉姆阴性分离物是ESBL生产者.
- 大肠杆菌 (43%) 和肺炎菌 (16%) 是最常见的病原体;大肠杆菌是最常见的ESBL生产者,主要来自尿样.
结论:
- 观察到产生ESBL的有机体,特别是大肠杆菌的高患病率.
- 需要采取紧急措施来制ESBLs的出现和传播.
- 这些发现强调了对抗微生物药物管理计划的需要.
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