中性粒细胞/淋巴细胞比率是一个准确而简单的工具,用于识别严重的急性胰腺炎,并预测死亡风险
Sourabh Kumar1, Nishitih M P Ekka1, Dipendra K Sinha1
1Department of Surgery, Rajendra Institute of Medical Sciences, Ranchi, India.
Journal of family medicine and primary care
|December 17, 2025
概括
中性粒细胞与淋巴细胞的比率 (NLR) 有效地预测严重急性胰腺炎 (SAP) 早期. 这种简单的生物标志物有助于患者分层,特别是在资源有限的环境中,为急性胰腺炎提供了更好的结果.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 血液学 血液学 血液学
- 关键护理医学 关键护理医学
背景情况:
- 急性胰腺炎 (AP) 是一种常见的胃肠道疾病,预后可变.
- 早期严重程度评估对于有效管理至关重要.
- 传统的AP严重性评分系统复杂且资源密集.
研究的目的:
- 评估中性粒细胞与淋巴细胞比率 (NLR) 对严重急性胰腺炎 (SAP) 的预测准确度.
- 为了建立最佳的NLR切割值来预测SAP严重程度在不同日后入院.
- 评估NLR和常见的AP并发症之间的相关性.
主要方法:
- 一项涉及110名被诊断患有AP的患者的预测准确性研究.
- 中性粒细胞与淋巴细胞比率 (NLR) 值在第0,1,2和3天被测量.
- 后勤回归和接收器运行特征 (ROC) 曲线被用于确定NLR的最佳切断值,以区分轻度AP (MAP) 与SAP.
主要成果:
- 与MAP相比,SAP患者的NLR值在所有测量日均显著高于MAP患者.
- 预测SAP的最佳NLR截止值从0日的5.66下降到3日的2.96,曲线下面面积 (AUC) 值很高.
- 酒精 (57%) 和胆结石 (38%) 是AP的主要原因;急性肺损伤 (24.5%) 是最常见的并发症.
结论:
- 中性粒细胞与淋巴细胞的比率 (NLR) 是一种可靠且简单的生物标志物,用于早期预测严重急性胰腺炎 (SAP).
- 由于NLR的易用性和准确性,它对分层AP患者非常有价值,特别是在资源有限的环境中.
- 建议进行进一步的研究,将NLR纳入急性胰腺炎管理的临床方案.
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