年龄调整的内脏脂肪指数与骨关节炎风险的相关性:来自NHANES 1999-2018年的横截面研究
Feng Chen1,2,3, Hao Lin4, Jing Xu5
1Department of Child Healthcare, Wenzhou People's Hospital, Zhejiang Province, China.
Archives of medical science : AMS
|December 17, 2025
概括
年龄调整的内脏脂肪指数 (AVAI) 与骨关节炎 (OA) 患病率正相关. AVAI显示OA的诊断性能比传统的肥胖指标更好.
科学领域:
- 类风湿病学 类风湿病学
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 肥胖和衰老是骨关节炎 (OA) 的独立危险因素.
- 越来越多地认识到内脏脂肪是代谢和炎症疾病的重要贡献者.
研究的目的:
- 评估年龄调整的内脏脂肪指数 (AVAI) 与骨关节炎 (OA) 的患病率之间的相关性.
- 将AVAI的诊断性能与OA检测的传统肥胖指数进行比较.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (1999-2018) 的横截面研究.
- 分析包括接收器操作特征 (ROC) 回归,多变量后勤回归,受限立方线 (RCS) 回归和子组分析.
- 队列包括20628名参与者,其中2297人被诊断患有OA.
主要成果:
- 在增加AVAI四分位数和OA患病率 (p < 0.001) 之间观察到显著的正相关性.
- 后勤回归表明,AVAI是关节炎风险的显著积极预测因素 (OR = 1.14,95% CI: 1.06,1.23).
- 与传统的肥胖指数相比,AVAI显示了OA的优越诊断性能 (AUC = 0.757).
结论:
- 这项研究确立了AVAI和OA患病率之间的显著积极关联.
- 与传统的肥胖指标相比,AVAI在识别OA方面表现出更强大的诊断效用.
- 这些研究结果表明,AVAI可能作为一个有价值的生物标志物用于OA风险评估.
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