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炎症性细胞因子和前列腺癌之间的关联:双向的门德尔随机化研究

Sheng Li¹, Libing Zhou¹, Tielin Wu¹

¹Ningbo Medical Centre LiHuiLi Hospital, China.

Archives of medical science : AMS

|December 17, 2025

概括

高水平的炎症性细胞因子如IL-6和FGF23与前列腺癌 (PCa) 风险增加有关. 相反,较低的IL22RA1水平也可能导致PCa的发展.

科学领域:

遗传学和流行病学
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

前列腺癌 (PCa) 是一个重要的全球健康问题.
炎症性细胞因子在PCa病因学中的作用需要进一步阐明.
门德尔随机化 (MR) 提供了一个强大的方法来调查因果关系.

研究的目的:

通过双向两样MR分析,研究91种炎症性细胞因子和前列腺癌 (PCa) 之间的潜在因果关系.
确定与PCa风险和进展相关的新型细胞因子生物标志物.

主要方法:

进行了一种双向的双样本孟德尔随机化 (MR) 分析.
逆方差加权 (IVW) 是主要方法,加权中位数 (WM) 和 MR Egger 补充.
灵敏度分析包括科克兰的Q测试和MR-Egger截取测试.

主要成果:

较高水平的C-C动机化学素20 (CCL20),C-C动机化学素23 (CCL23),纤维细胞生长因子19 (FGF19),纤维细胞生长因子23 (FGF23) 和介质素-6 (IL-6) 显示出与PCa的积极因果关系.
介素-6 (IL-6) 显示出最强的积极效应,其次是CCL20和FGF23.
观察到PCa和互白素-22受体亚单元α-1 (IL22RA1) 水平之间存在负因果关系,这表明IL22RA1降低与PCa发展有关.

结论:

结果表明,CCL20,CCL23,FGF19,FGF23和IL-6的水平增加与患PCa的风险更高有关.
证据支持降低IL22RA1在PCa病变发生过程中的因果作用.
这些细胞因子代表了PCa预防和治疗的潜在治疗点.

关键词:

门德尔的随机化炎症性细胞因子是炎症性细胞因子.前列腺癌是前列腺癌.

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