肠道微生物群和失眠:孟德尔的随机化和网络药理学,以预测传统中医的潜在干预
Xu Wang1,2,3, Jie Zhang1,3, Xiao-Yu Song1,2,3
1Center of Encephalopathy, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Archives of medical science : AMS
|December 17, 2025
概括
这项研究使用了门德尔的随机化来将特定的肠道微生物群 (GM) 与失眠风险联系起来,确定了针对性干预的潜在传统中医药 (TCM). 研究结果表明,转基因调节可能提供新的失眠治疗策略.
科学领域:
- 遗传学 是一个遗传学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 失眠是一种普遍存在的睡眠障碍,具有复杂的病因.
- 肠道微生物群 (GM) 在宿主生理学中起着至关重要的作用,包括神经功能.
- 了解转基因生物和失眠之间的遗传联系对于开发新的治疗策略至关重要.
研究的目的:
- 使用孟德尔随机化 (MR) 识别肠道微生物群 (GM) 对失眠的遗传因果影响.
- 预测潜在的中国传统医药 (TCM) 用于在失眠中进行转基因向干预.
- 探索连接GM和失眠的潜在信号通路.
主要方法:
- 对转基因和失眠的全基因组关联研究 (GWAS) 总结数据进行了分析.
- 门德尔随机化 (MR) 分析,主要使用反变量加权 (IVW) 方法,评估遗传相关性.
- 进行了功能丰富分析和数据库挖掘 (CTD,Coremine),以确定路径和TCM.
主要成果:
- 七个转基因植物,包括Ruminococcaceae和Marvinbryantia,与失眠风险 (增加或减少) 有遗传关联.
- 关键的信号通路涉及的神经活性联结体受体相互作用和哺乳动物的目标拉巴胺素 (mTOR).
- 已发现的潜在的TCM包括帕纳克斯人参,Curcuma aromatica和Glycyrrhizae Radix et Rhizoma.
结论:
- 特定的肠道微生物群 (GM) 与失眠的发展有遗传联系.
- 转基因可能通过mTOR和神经活性联体受体相互作用等途径影响失眠.
- 这项研究为探索通过向肠道微生物群来治疗失眠的TCM提供了基础.
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