益生菌和肠道紧密结合屏障的功能
Megan M Ferris1, Ligia Subitoni Antonio1, Rana Al-Sadi1
1Frederick F. Paustian IBD Center, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
益生菌可以帮助维持和恢复肠道屏障功能,这对于预防胃肠道疾病至关重要. 特定菌株通过各种机制增强肠道上皮质完整性.
科学领域:
- 胃肠道学和微生物学
- 肠道屏障的功能是肠道屏障.
- 益生菌研究的研究.
背景情况:
- 肠上皮质紧接点 (TJ) 的破坏是胃肠道 (GI) 疾病的核心.
- 肠道微生物群影响上皮质的完整性.
- 益生菌为肠道疾病提供潜在的治疗策略.
研究的目的:
- 审查有关益生菌对肠道上皮质TJ屏障功能的保护作用的文献.
- 总结益生菌调节屏障完整性的机制.
- 突出益生菌在肠道疾病中的治疗潜力.
主要方法:
- 对益生菌和肠道屏障功能研究的文献综述.
- 从细胞培养,动物模型和临床环境中分析数据.
- 检查益生菌作用的分子机制.
主要成果:
- 特定的益生菌菌株 (Lactobacillus,Bifidobacterium,E. coli Nissle 1917,B. subtilis,S. boulardii) 增强了屏障的完整性. 在这种情况下,我们可以使用微生物.
- 益生菌可以提高TJ蛋白的调节,抑制炎症,调节信号通路 (NF-κB,MLCK,MAPK).
- 益生菌可以激活宿主模式识别受体 (TLR-2,PPARγ).
结论:
- 益生菌具有作为肠胃疾病的辅助或预防疗法的潜力,具有上皮屏障功能障碍.
- 菌株特异性效应显而易见,强调了对特征的需要.
- 为了有效的益生菌干预,需要进一步的研究,临床试验和标准化.
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