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Updated: Jan 8, 2026

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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一个新开发的TGF-β-响应的CAR T细胞,用于增强增殖和细胞因子分泌

Shafieeh Mansoori1,2, Mohammad Ali Shokrgozar3, Monireh Gholizadeh1,4

  • 1Department of Immunology, Pasteur Institute of Iran, Tehran, Iran.

Advanced pharmaceutical bulletin
|December 17, 2025
PubMed
概括

化学抗原受体 (CAR) 的T细胞被改造为准TGF-β受体II (TGF-βRII),在固体瘤中克服免疫抑制. 这些新型CAR T细胞在富含TGF-β的环境中表现出增强的激活,增殖和细胞因子释放.

关键词:
采用细胞免疫疗法采用细胞免疫疗法化学抗原受体治疗 化学抗原受体治疗免疫抑制是一种免疫抑制.固体瘤是一个固体瘤.转化增长因子β的转化增长因子β.瘤微环境是一个微环境.

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