抗生素的使用和多发性硬化症的风险:系统性审查和元分析
Abdorreza Naser Moghadasi1, Mohsen Rastkar2,3, Maryam Feili4
1Multiple Sclerosis Research Center, Neurosciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Maedica
|December 17, 2025
概括
除了青素之外,使用抗生素可能会增加患多发性硬化症 (MS) 的风险. 这次系统性审查和元分析研究了肠-大脑轴和抗生素对MS风险的影响.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 肠-大脑轴描述了肠和神经系统之间的双向通信.
- 抗生素可以破坏这一关键的肠-大脑轴.
- 抗生素暴露对诸如多发性硬化症 (MS) 等神经系统疾病的潜在影响需要进行调查.
研究的目的:
- 进行系统审查和元分析.
- 确定抗生素的使用是否与患多发性硬化症 (MS) 的风险增加有关.
主要方法:
- 在六个主要数据库 (PubMed,Scopus,EMBASE,PsycINFO,Web of Science,Google Scholar) 进行了全面的文献搜索.
- 数据提取由两名独立研究人员进行,包括研究细节,参与者人口统计和使用的抗生素类型.
- 六项研究符合系统性审查和元分析的纳入标准.
主要成果:
- 分析包括了关于青素,四环素,硫胺,类和类的数据.
- 青素使用与MS风险没有显著关联 (OR=1.01,95% CI:0.84-1.22).
- 在增加的MS风险和使用四环素 (OR=1.20),硫胺 (OR=1.30),类 (OR=1.19) 和类 (OR=1.24) 之间发现了显著的关联.
结论:
- 除了青素之外,抗生素的使用可能与多发性硬化症 (MS) 的风险增加有关.
- 需要进一步的研究来阐明肠-大脑轴背后的机制以及抗生素对MS病变发生的影响.
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