Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Probiotics01:22

Probiotics

299
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
299
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

222
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
222
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

254
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
254

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Extracellular vesicles as indicators of environmental stress response in <i>Lactiplantibacillus plantarum</i>.

Extracellular vesicles and circulating nucleic acids·2026
Same author

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations.

Pediatric blood & cancer·2026
Same author

Resistant Insistent Persistent: A Global Call by Mental Health Nursing Leaders.

International journal of mental health nursing·2026
Same author

The food grade bacterium Lactobacillus helveticus VEL12193 promotes autophagy by releasing membrane vesicles.

Cell communication and signaling : CCS·2026
Same author

Beyond Resilience: Resources, Respect and Recognition in Global Universal Mental Health Nursing Reform.

Journal of psychiatric and mental health nursing·2025
Same author

[Upper-gastrointestinal tract toxicities associated with Immune Checkpoint Inhibitors (ICI)].

Bulletin du cancer·2025

相关实验视频

Updated: May 6, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

23.2K

肠道生物工程模型用于研究宿主-微生物群-益生菌相互作用.

Elise Delannoy1, Alexandre Grassart1, Catherine Daniel1

  • 1Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France.

Microbiome research reports
|December 17, 2025
PubMed
概括

动物模型对于研究肠道微生物相互作用是有限的. 肠上芯片技术为探索宿主微生物动态和人类益生菌效应提供了一个有希望的替代方案.

科学领域:

  • 微生物学 微生物学
  • 免疫学 免疫学 免疫学
  • 生物技术是生物技术.

背景情况:

  • 胃肠道是宿主微生物相互作用的关键地点,对于哺乳动物的恒温是必不可少的.
  • 益生菌可以调节肠道微生物群并提供健康益处,但它们的机制需要进一步研究.
  • 目前的动物模型在翻译相关性方面存在局限性,并引发了伦理方面的担忧.

研究的目的:

  • 讨论研究宿主-微生物相互作用的替代模型.
  • 在这个领域探索肠上芯片技术的潜力.
  • 在组织层面描述宿主-微生物和益生菌相互作用.

主要方法:

  • 对当前动物模型 (小鼠,非动物) 的审查.
  • 介绍微流体器官在芯片上的技术,特别是肠在芯片上的模型.
  • 讨论监测微生物的时空动态.

主要成果:

  • 动物模型提供了一个基础,但有翻译和道德限制.
  • 肠上芯片模型保持了组织复杂性和个体间的可变性.
  • 这些先进的模型可以更好地描述宿主-微生物和益生菌相互作用.
关键词:
益生菌 益生菌 益生菌在这里,我们可以看到子子.在芯片上的肠道.主体-微生物群的相互作用

更多相关视频

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
10:24

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Published on: July 4, 2018

12.2K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.2K

相关实验视频

Last Updated: May 6, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

23.2K
Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
10:24

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

Published on: July 4, 2018

12.2K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.2K

结论:

  • 肠上芯片技术代表了研究人类肠道微生物相互作用的重大进展.
  • 与传统的动物模型相比,这些模型提供了更可翻译和更道德的方法.
  • 使用肠上芯片系统的进一步研究将增强我们对益生菌疗效和肠道平衡的理解.