循环细胞粘附分子作为炎症性肠病中的生物标志物:系统性审查和元分析
Krzysztof Przęczek1,2, Dorota Cibor1, Małgorzata Zwolińska-Wcisło1
1Department of Gastroenterology and Hepatology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.
可溶性细胞间粘附分子-1 (sICAM-1) 和可溶性E-选择素 (sE-选择素) 在炎症性肠病 (IBD) 中升高. sICAM-1可以作为活跃IBD的生物标志物,表明疾病发病过程中的内皮损伤.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 生物标志物发现发现
背景情况:
- 内皮功能障碍是炎症性肠病 (IBD) 病原体的组成部分.
- 可溶性细胞粘附分子 (CAMs) 可能表明内皮损伤和疾病活动.
- 关键的CAMs包括sICAM-1,sVCAM-1,sMAdCAM-1和selectins. 这两种类型的CAMs是最常见的.
研究的目的:
- 系统地审查和分析IBD患者与对照者的CAM水平.
- 评估与IBD疾病活动和类型 (克罗恩病与性结肠炎) 相关的CAM.
- 为了确定IBD活动的潜在生物标志物.
主要方法:
- 在PubMed,Embase,Web of Science和Scopus的系统搜索.
- 包括26项研究,将IBD患者与健康对照组或IBD亚组进行比较.
- 使用修改后的纽卡斯尔-太华尺度评估偏差风险.
主要成果:
- IBD患者的sICAM-1和sE-selectin水平高于对照组.
- 在克罗恩病和性结肠炎中都观察到升高的sICAM-1.
- 较高的sICAM-1水平与活跃疾病相关,表明生物标志物潜力.
结论:
- 循环中的sICAM-1和sE-selectin在IBD中升高,支持内皮损伤的作用.
- sICAM-1显示出作为一个生物标志物来区分活性IBD和非活性IBD的前景.
- 进一步的研究可能会阐明这些CAM在IBD管理中的确切作用.
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