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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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循环素依赖性激酶 (CDK) PROTAC在癌症治疗中的最新发展

Arijit Nandi1, Anwesha Das2, M Rhia L Stone1

  • 1Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, Brisbane 4067, Queensland Australia.

ACS medicinal chemistry letters
|December 17, 2025
PubMed
概括

基于循环素依赖激酶 (CDK) 的蛋白质溶解向基因组 (PROTACs) 在癌症治疗方面表现有前途. 本综述涵盖了2024年CDK向PROTAC的进展,包括计算选,链接器策略和E3结合酶应用.

关键词:
奇美拉 Chimera 奇美拉 Chimera 奇美拉 Chimera 奇美拉 Chimera 奇美拉 Chimera 奇美拉 Chimera 奇美拉它们是异性双功能的.氨酸-氨酸三氨酸激酶有针对性的蛋白质降解降解.三元复合体是一个三元复合体.

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