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饮食中的3'-sialyllactose减少了家庭灰尘虫诱导的急性过敏喘模型中的敏感化和2型炎症
M Zuurveld1, J W M de Kleer1, I van Ark1
1Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.
Frontiers in allergy
|December 17, 2025
概括
人类牛奶寡糖 (HMOS),特别是3'sialyllactose (3'SL) 和6'sialyllactose (6'SL),显示出预防过敏性喘的潜力. 虽然这两种药物都能降低小鼠的呼吸道过敏反应,但3'SL可以保护小鼠免受室内灰尘引发的喘发作.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- 营养科学 营养科学
背景情况:
- 过敏性喘是一种T助手类型2免疫反应,影响全球数百万人,其特点是异敏症和支气管过敏反应.
- 人类牛奶寡糖 (HMOS) 具有免疫调节特性,可以预防婴儿喘等过敏疾病.
研究的目的:
- 为了研究两个化HMOS,3'-sialyllactose (3'SL) 和6'-sialyllactose (6'SL) 的疗效,在室内灰尘虫 (HDM) 诱导的过敏喘的小鼠模型中.
- 评估3'SL和6'SL对气道过敏反应,免疫细胞透和炎症标志物的剂量依赖作用.
主要方法:
- 在HDM敏感化前和期间,BALB/c小鼠被食含有不同度的3'SL或6'SL的食.
- 评估了气道的高响应性,并分析了支气管-气泡泡洗液 (BALF) 和肺组织的炎症标志物和免疫细胞群.
主要成果:
- 饮食3'SL和6'SL (在特定剂量下) 降低了HDM挑战小鼠的气道过敏反应.
- 3'SL的使用防止了HDM特异性IgE和mMCP1的增加,并减少了BALF的整体炎症细胞流入.
- 虽然0.5%的6'SL增加了乙氨基基和某些炎症性细胞因子,但3'SL显示了对过敏敏感和喘发展的保护作用.
结论:
- 在小鼠模型中,饮食3'SL和6'SL对过敏喘具有差异性,剂量依赖的影响.
- 3'SL通过减轻关键敏感化途径,有望预防HDM诱导的过敏喘.
- 对HMOS的进一步研究可能会为过敏呼吸道疾病揭示新的治疗策略.
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