在预测膀癌复发和生存方面评估分子和免疫生物标志物:系统性审查
Saad Masood1, Abdullah Shaikh2, Yasin Brar3
1Urology, York and Scarborough Teaching Hospitals NHS Foundation Trust, York, GBR.
Cureus
|December 17, 2025
概括
分子和基因组生物标志物显著提高了膀癌复发预测. 综合分析提供了个性化的管理策略,改善了患者的治疗结果和监测.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 基因组学就是基因组学.
背景情况:
- 膀癌复发和预后预测仍然具有挑战性.
- 传统的方法往往缺乏足够的准确性来实现个性化管理.
研究的目的:
- 系统地审查关于膀癌复发和预后的分子和生物化学生物标志物的证据.
- 评估各种生物标志物类型的预测和预后效用.
主要方法:
- 在PubMed,Scopus和Web of Science的综合文献搜索到2025年9月.
- 在对347个记录进行严格选后,包括了五项研究.
- 分析各种生物标记物,包括ctDNA,免疫标记物,甲基化和基因表达模型.
主要成果:
- 综合分子分析显著改善了超出临床病理因素的复发和进展的预测.
- 免疫和基因组生物标志物显示出早期复发检测的潜力.
- 甲基化和酶标记物有助于预后分层.
结论:
- 以生物标志物为指导的监测和个性化管理在膀癌中具有临床价值.
- 强调了对生物标志物测试进行大规模验证和标准化的需要.
- 分子分析提供了更好的预测膀癌的结果.
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