墨西哥年轻人内化-外化特征的遗传责任:逆境的适度
Zuriel Ceja1,2, I-Tzu Hung3, Nathaniel Thomas3
1Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
medRxiv : the preprint server for health sciences
|December 17, 2025
概括
内部化-外部化特征的共同遗传因素预测了墨西哥年轻人的精神疾病. 环境逆境,如父母的丧失,进一步增加疾病的风险,突出需要综合遗传和环境方法.
科学领域:
- 精神病学基因组学 精神病学基因学
- 青少年心理健康 青少年心理健康
- 行为遗传学 行为遗传学
背景情况:
- 内部化 (INT) 和外部化 (EXT) 的特征是精神病理学的常见维度.
- 对墨西哥年轻人来说,了解这些特征的遗传结构及其与疾病的联系至关重要.
- 环境不利因素可能与遗传负担相互作用,影响疾病的发展.
研究的目的:
- 调查INT和EXT特征的遗传责任,以预测墨西哥青少年的相应疾病.
- 检查环境逆境是否能缓和遗传因素与精神疾病之间的关联.
- 探索共享和特定的遗传影响在内部化和外部化精神病理学.
主要方法:
- 在全基因组关联总结统计数据上利用基因组结构方程建模 (SEM) 来推导潜在遗传因素的多基因分数 (PGS).
- 评估了1,130名墨西哥青少年 (12-17岁) 的精神病诊断和逆境,使用世界心理健康综合国际青少年诊断访谈.
- 采用多项逻辑回归来测试PGS,逆境和障碍结果之间的关联.
主要成果:
- 一个共享的内部化-外部化因子 (INT-EXT-F) 和特定因子 (INT-SF,EXT-SF) 最适合遗传数据.
- 较高的INT-EXT-FPGS与仅外部化和并发性疾病的风险增加有关.
- 父母丧生和累积的逆境缓和了特定遗传因素 (EXT-SF PGS) 对内化,外化和并发性疾病的影响.
结论:
- 遗传和环境因素相互作用,影响墨西哥年轻人的精神疾病风险.
- 研究结果支持将基因和环境研究整合到不同人群中的实用性.
- 这项研究将精神病学基因组研究的范围扩大到欧洲祖先之外.
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