在"我们所有人"研究计划中,大麻使用和类似精神病的经历
Emma C Johnson1, Zhen Luo1, Pamela N Romero Villela1
1Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
medRxiv : the preprint server for health sciences
|December 17, 2025
概括
大麻使用与精神病类似体验 (PLEs) 有关. 然而,这些关联可能是由于其他物质的使用,而不是大麻本身,这表明需要进一步研究.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 大麻的使用越来越普遍,同时有越来越多的精神病类似经历 (PLEs) 报告.
- 了解大麻和PLEs之间的关系至关重要,尤其是在日益合法化的背景下.
- 之前的研究表明存在联系,但混因素需要调查.
研究的目的:
- 在当代美国人口中调查大麻使用和PLEs之间的关联.
- 为了确定这种关联是否在调整其他风险因素之后仍然存在,包括物质使用和对精神分裂症的遗传倾向.
- 区分大麻与其他物质在PLEs发展中的作用.
主要方法:
- 从"我们所有人"研究计划 (N=62,153) 的自我报告数据的横截面分析.
- 检查了四种类型的自我报告的PLEs:听觉和视觉感知扭曲,参考思想和迫害思想.
- 根据精神分裂症的个人/家庭病史,精神分裂症多遗传责任和终身使用其他物质进行调整.
主要成果:
- 大麻使用与所有四种类型的PLEs有关,即使在调整了与精神分裂症相关的因素之后.
- 然而,在调整其他物质使用时,大麻使用和PLEs之间的关联消失了.
- 甲基胺,香烟和阿片类药物的使用仍然与PLEs有显著的关联.
结论:
- 大麻使用和PLE之间观察到的联系可能会被其他物质的使用所混.
- 单独使用大麻可能不是PLEs的直接原因.
- 未来的研究应该解开大麻与PLEs中的其他物质之间的病因作用.
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