经更年期妇女口腔微生物特征与整体骨密度之间的相关性,基于宏观基因组分析
Man Liu1,2, Min Wu3, Yongjun Tang4
1Department of Preventive Dentistry, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Frontiers in cellular and infection microbiology
|December 17, 2025
概括
这项研究揭示了在患有骨质疏松症的绝经后妇女和健康个体之间口腔细菌的显著差异. 这些发现表明,口腔微生物群与绝经后骨质疏松症 (PMO) 之间存在联系.
科学领域:
- 微生物组研究的研究.
- 口腔健康 口腔健康
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 绝经后骨质疏松症 (PMO) 与雌激素缺乏和骨微型结构恶化有关,增加骨折风险.
- 新兴研究强调了口腔和肠道微生物群在PMO中的作用,提出了一个"口腔-肠道-骨轴".
- 了解口腔微生物组对PMO的贡献对于开发新型治疗策略至关重要.
研究的目的:
- 调查口腔微生物群组成和功能与绝经后骨质疏松症 (PMO) 之间的关系.
- 确定与骨矿物质密度 (BMD) 降低相关的特定口腔微生物物种和代谢途径.
- 探索口腔微生物群作为PMO检测生物标志物的潜力.
主要方法:
- 从21名绝经后妇女 (50-60岁) 的唾液和牙斑样本的基因组测序.
- 基于BMD测量 (DXA) 的骨质疏松症,骨质疏松症和健康组的参与者的分类.
- 分析微生物多样性,社区结构 (LEfSe),功能途径 (KEGG) 和预测建模 (LASSO,随机森林).
主要成果:
- 在骨质疏松症和健康组之间观察到唾液微生物结构的显著差异 (P=0.041).
- 在骨质疏松症和骨质疏松症组中,特定的细菌物种如*Aggregatibacter*和*Streptococcus pneumoniae*在骨质疏松症和骨质疏松症组中差异丰富.
- 预测模型显示了初步的区分能力 (骨质疏松症与健康的AUC为0.82,骨质疏松症与健康的AUC为0.74).
结论:
- 在绝经后的女性中,口腔微生物群的组成和功能发生了显著的变化,骨密度不同.
- 特定的口腔细菌和代谢途径 (例如,糖甘生物合成,胆代谢) 与PMO有关.
- 这些发现为口腔微生物群和PMO之间的联系提供了初步证据,需要在更大的队列中进一步调查.
相关概念视频
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:31Essential Minerals for Bone Health
5.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.9K
01:40Bone Remodeling
40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K
01:25Role of Vitamins in Maintaining Bone Health
5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K