支气管髓状肉瘤是急性单质白血病 (AML-M5) 的次要病例:一个罕见的病例报告
Zhen Yang1, Yuzhi Lu1, Shenglan Ye1
1Department of Respiratory and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Frontiers in medicine
|December 17, 2025
概括
本病例报告详细介绍了一名患有急性髓性白血病 (AML-M5) 的患者在静脉治疗期间罕见的支气管髓性肉瘤 (BMS). 包括化疗和干细胞移植在内的多模式治疗实现了完全缓解.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 支气管髓性肉瘤 (BMS) 是一种罕见的急性髓性白血病 (AML) 的异常表现.
- 在此之前,全球仅报告了8例BMS病例.
- BMS可以潜伏地呈现肺部症状,可能导致误诊.
研究的目的:
- 报告第九个记录的BMS病例.
- 描述在治疗急性单质白血病 (AML-M5) 期间发生BMS的情况.
- 突出这一罕见疾病的诊断和治疗挑战.
主要方法:
- 一个47岁的男性患有AML-M5.5的病例介绍.
- 通过内支气管活检和免疫组织化学分析证实了诊断.
- 治疗包括救援化疗,以阿扎西蒂丁和维内托克拉克斯巩固,然后进行全源造血干细胞移植 (HSCT).
主要成果:
- 患者在采用多模式治疗策略后实现了完全缓解.
- 短期随访显示持续的无疾病生存率.
- 支气管通透度和血液学参数正常化.
结论:
- 在新的向疗法 (如venetoclax) 期间,BMS可能会出现.
- 结合顺序化疗和高血压治疗的多式疗法对BMS有效.
- 早期怀疑和彻底评估对于管理AML患者肺部症状至关重要.
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