产前对空气污染颗粒物的暴露预测了儿童时期的动脉硬
Eleni Renaers1, Hanne Croons1, Thessa Van Pee1
1Centre for Environmental Sciences, Hasselt University, Agoralaan Gebouw D, 3590 Diepenbeek, Belgium.
European journal of preventive cardiology
|December 17, 2025
概括
怀孕期间暴露于细颗粒物 (PM2.5) 与儿童的动脉硬度增加有关. 这种早期的暴露可能会增加未来心血管疾病 (CVD) 的风险.
科学领域:
- 环境健康 环境健康
- 儿童心脏病学 儿童心脏病学
- 流行病学 流行病学
背景情况:
- 早期的环境暴露显著影响胎儿编程和长期健康结果.
- 产前暴露于细颗粒物 (PM2.5) 是晚年患心血管疾病 (CVD) 的潜在危险因素.
研究的目的:
- 调查儿童在产前暴露于PM2.5和脉冲波速度 (PWV) 之间的关联.
- 为了评估动脉硬性作为心血管风险的标志物,在子宫内暴露于空气污染的儿童.
主要方法:
- 预期出生队列研究 (ENVIRONAGE) 随访9至11岁儿童.
- 动脉硬度用Vicorder®装置测量,使用带-椎PWV进行测量.
- 用于估计每日产前PM2.5暴露的高分辨率时空建模;通过线性回归和分布式滞后非线性模型 (DLNM) 进行统计分析.
主要成果:
- 第二季度PM2.5暴露量的5μg/m3增加与0.09m/sec更高的PWV (P=0.03) 相关.
- 即使考虑到儿童PM2.5暴露,第二个月的暴露仍然是PWV (0.08m/sec,P=0.05) 的重要预测因素.
结论:
- 儿童PWV是未来心血管风险的指标.
- 在第二个三个月内产前暴露于PM2.5与儿童的动脉硬度增加有关.
- 这些发现突出了由于孕期暴露于空气污染而导致儿童长期心血管后果的可能性.
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