特兰胺酸对心脏手术后的术后痴呆症没有剂量依赖的影响 - 一项回顾性队列研究
Rachel Wong1, Scott Minns2, Florian Falter1
1Royal Papworth Hospital, Cambridge Biomedical Campus, Cambridge CB2 0AY, UK.
The journal of extra-corporeal technology
|December 17, 2025
概括
较高剂量的特兰胺酸并没有减少心脏手术患者的术后狂妄症. 在这项研究中,在不同的特兰胺酸剂量组中, Delirium 发生率没有显著差异.
科学领域:
- 心脏病学 心脏病学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后痴呆症 (POD) 是心脏手术后的一种常见并发症.
- 神经炎症和血脑屏障的破坏与POD的发展有关.
- 特兰胺酸 (TXA) 可能减轻神经炎症并稳定血脑屏障.
研究的目的:
- 为了研究特兰胺酸对术后狂妄发病率的剂量依赖作用.
- 为了确定较高的TXA剂量是否可以在心肺绕道心脏手术后减少POD.
主要方法:
- 对5525名心脏手术患者进行了回顾性观察数据库研究.
- 患者根据tranexamic acid的剂量 (高达22 mg/kg,22.01-27 mg/kg,>27.01 mg/kg) 分为三组.
- 使用重症监护室 (CAM-ICU) 混乱评估方法评估的术后妄想.
主要成果:
- 在三个TXA剂量组中,术后狂妄的发生率没有统计学上显著的差异.
- Delirium 发病率为 18% (A 组),17% (B 组) 和 20% (C 组),与整体队列 (18%) 一致.
- 0.25的P值表明TXA剂量对妄率没有显著影响.
结论:
- 这项研究不支持这样的假设,即更高剂量的西胺酸可以减少手术后妄想.
- 目前的证据并没有表明增加特兰胺酸剂量对预防心脏手术患者的妄想有好处.
关键词:
心脏外科手术是一项心脏手术.通过心肺绕道术 (cardiopulmonary bypass) 进行心肺绕道.结果结果的结果.手术后妄症 术后妄症手术后的神经认知能力下降.特兰克萨姆酸是什么意思更多相关视频
08:50Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
Published on: March 26, 2018
12.2K
04:48Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
Published on: November 28, 2018
8.3K
相关概念视频
01:28Cardiomyopathy VII: Pre and Post Operative Nursing Management
257
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
257
01:24General Anesthesia: Overview
547
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
547
01:18Effects of EDTA on End-Point Detection Methods
600
Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
600
01:26Cardiac Catheterization IV: Nursing Management
606
Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
606
01:30Acute Coronary Syndrome III: Diagnostic Studies
197
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
197