在接受抗逆转录病毒疗法治疗的患者中,一线治疗方案的切换存在隐藏风险
Shira Kimberley1, Mergan Naidoo
1Department of Haematology, Faculty of Health, Victoria Mxenge Hospital, Durban. kimberleyshira@gmail.com.
概括
基于多卢特格拉维尔 (DTG) 的艾滋病毒治疗在南非是首选的,但从埃法维伦兹 (EFV) 转换增加了高血压和脏疾病. 需要仔细监测长期影响.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 多卢特格拉维尔 (DTG) 是南非首选的一线艾滋病毒治疗方法,原因是耐受性和疗效比 efavirenz (EFV) 更好.
- 人们对基于DTG的疗法对艾滋病毒感染者 (PLHIV) 的长期心血管,代谢和的影响存在担忧.
- 这项研究比较了患者的结果,在tenofovir,emtricitabine和efavirenz (TEE),tenofovir,lamivudine和dolutegravir (TLD),和那些从TEE切换到TLD.
研究的目的:
- 为了比较PLHIV在TEE,TLD和TEE到TLD切换方案中的人口和临床结果.
- 评估切换到基于DTG的治疗的长期代谢和脏后果.
主要方法:
- 在KwaZulu-Natal的一个城市地区医院进行了回顾性分析研究.
- 用统计能力计算的212名患者的样本大小.
- 在基线,6个月和12个月收集的数据,使用SPSS版本28.0.0进行分析.
主要成果:
- 从TEE转换为TLD的组显示,新高血压 (9.9%) 和慢性病 (CKD) (12.1%) 的发生率显著更高.
- TLD组保持了稳定的临床结果.
- 在TEE群体中,新诊断的脂质不良症的发病率最高.
结论:
- 基于DTG的治疗仍然是南非首选的HIV治疗方案.
- 从EFV切换到DTG需要对长期代谢和脏影响进行仔细监测.
- 切换组中高血压和CKD的增加率需要对患者进行更密切的监测.
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