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一种基于细菌细胞壁的多功能纳米药物,用于口腔状细胞癌组合治疗

Aijing Ma¹, Chuiyin Wang¹, Yabo Wang¹

¹The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China. yangxiaoying@tmu.edu.cn.

Biomaterials science

|December 17, 2025

概括

这项研究开发了一种新的纳米药物,使用细菌细胞壁来治疗口腔癌. 通过激活免疫反应,该疗法有效抑制了口腔状细胞癌的复发和转移.

科学领域:

生物材料科学生物材料科学
纳米医学是一种纳米医学.
癌症治疗癌症治疗

背景情况:

口腔状细胞癌 (OSCC) 是一种具有高复发率和转移率的侵袭性癌症.
细菌免疫疗法通过刺激免疫反应,为癌症治疗提供了一个有希望的方法.
Porphyromonas gingivalis (Pg) 细胞壁 (PgCW) 含有μ-oxo bisheme,提供过氧酶模仿,声动力学和化学动力学治疗活动,以及免疫辅助性质.

研究的目的:

开发一种多功能纳米药物用于OSCC组合治疗.
为了利用PgCW作为一种治疗剂,加载在半孔纳米球上.
研究纳米药物 (DT@PgCW) 诱导免疫细胞死亡和抑制OSCC的疗效.

主要方法:

在树突性大孔性中孔性二氧化纳米球上合成了中孔性TiO2.
将PgCW加载到纳米结构中以创建DT@PgCW.
评估了DT@PgCW在超声波照射下对反应性氧物种生成和OSCC细胞死亡诱导的性能.

主要成果:

DT@PgCW通过声动力学疗法,化学动力学疗法,H2O2分解和谷氨耗尽产生了活性氧物种.
用DT@PgCW进行超声波照射在OSCC细胞中诱导免疫细胞死亡.
释放的瘤抗原和PgCW的免疫辅助特性引起了强大的免疫反应,抑制了OSCC的复发和转移.

结论:

开发了一种基于细菌细胞壁的多功能纳米医学 (DT@PgCW) 用于OSCC治疗.
通过使用多模式效应,展示了OSCC组合治疗的有效策略.
该纳米药物显示出通过利用内在的免疫辅助特性来抑制OSCC复发和转移的潜力.

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