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Updated: Jan 8, 2026

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Published on: April 4, 2025

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APE1活动由单链和双链G-四联构造中的非G-四联构造控制

Brianna L Trabucco1, Aaron M Fleming1, Cynthia J Burrows1

  • 1Department of Chemistry, University of Utah, Salt Lake City, USA.

Chemistry (Weinheim an der Bergstrasse, Germany)
|December 17, 2025
PubMed
概括

阿普里尼克/阿普里米尼克内核酶-1 (APE1) 有效地切割非正规的DNA结构,而不仅仅是标准的双重组. 它的活性随着G-四折叠的增加而降低,显示结构控制修复酶功能.

关键词:
在APE1中,APE1是APE1.亚巴斯基遗址 (Abasic sites) 是一个亚巴斯基遗址.造成的DNA损伤是DNA损伤.在G-四重复合体中.结核酸酶 (endonucleases) 是一种可以在细胞内形成的核酸.

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