[风湿性关节炎患者焦虑抑郁症状,疾病活动和残疾程度之间的关系]
Anne-Marie Chassin-Trubert C1, César Lillo D2, Stephanie Prieto S2
1Sección de Reumatología, Hospital Clínico Universidad de Chile, Santiago, Chile.
Revista medica de Chile
|December 17, 2025
概括
近一半的类风湿性关节炎 (RA) 患者出现焦虑和抑郁症状. 与没有情绪障碍症状的患者相比,这些患者的疾病活动和残疾水平显著更高.
科学领域:
- 类风湿病学 类风湿病学
- 精神病学是一个精神病学.
- 临床医学 临床医学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性炎症性疾病,影响身体和心理社会福祉.
- 人们承认RA与焦虑和抑郁等情绪障碍的同时发生,但缺乏明确的因果关系.
- 了解RA疾病活动和心理健康之间的相互作用对于全面的患者护理至关重要.
研究的目的:
- 为了研究抑郁和焦虑症状与类风湿性关节炎患者的疾病活动之间的关系.
- 评估情绪障碍症状与RA患者经历的残疾程度之间的相关性.
主要方法:
- 使用了经过验证的仪器,包括医院焦虑和抑郁量表 (HADS) 和健康评估问卷 (HAQ).
- 使用疾病活动指数-28 (DAS28),临床疾病活动指数 (CDAI) 和简化疾病活动指数 (SDAI) 评估疾病活动.
- 采用各种统计测试来分析情绪症状,疾病活动和残疾之间的关联.
主要成果:
- 在122名研究的RA患者中,有46%表现出焦虑和/或抑郁的症状.
- 患有焦虑/抑郁症状的患者对DAS28 (4.33比2.75),SDAI (17比7.5),CDAI (15比7) 和HAQ (1.18比0.29) 的平均得分显著更高 (所有p<0.001).
- 在经历情绪症状的RA患者中,较高的疾病活动指数和增加的残疾之间观察到强烈的相关性.
结论:
- 大约一半的类风湿性关节炎患者患有并发性焦虑和/或抑郁症.
- 增加的疾病活动和更大的身体残疾与RA患者的焦虑和/或抑郁症状的存在有显著关联.
- 这些发现强调了在RA治疗中查和管理情绪障碍的重要性.
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