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在为先天的十二指肠阻塞接受手术的患者中长期的胃肠道连续症
Adinda G H Pijpers1,2,3, Maaike Hogerwerf4,5,6,7, Fenne A I M Van den Bunder4,5,6
1Department of Pediatric Surgery, Emma Children's Hospital, Amsterdam University Medical Centers, location University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. a.pijpers1@amsterdamumc.nl.
出生十二指管阻塞手术患者报告与健康同龄人相似的长期胃肠道结果,尽管便秘更频繁. 三胞胎症21并没有显著改变这些结果.
科学领域:
- 儿科手术 儿科手术
- 胃肠病学 胃肠病学
- 遗传学 遗传学 是一个
背景情况:
- 原始的十二指管阻塞 (DO) 需要早期的手术干预.
- 经过DO手术后的长期胃肠道 (GI) 后续并未得到充分证实.
- 了解患者报告的结果测量 (PROM) 对长期护理至关重要.
研究的目的:
- 通过使用儿科生活质量库存TM (PedsQLTM) GI-Module 来评估DO患者的长期GI PROM.
- 为了比较DO患者和健康的对照组之间的PROMs.
- 评估DO患者的PROMs的差异,包括患有三发性病21和没有三发性病21.
主要方法:
- 从2023年9月到12月进行了一项横截面队列研究.
- 在PedsQLTM GI-Module问卷中,对在1999年至2022年期间接受过DO手术的患者进行了调查.
- 数据与已公布的健康对照组 (n=513) 与邦费罗尼校正进行了比较.
主要成果:
- 33/89 DO患者填写了问卷;平均年龄为13.3岁,19/33是女性.
- 在DO患者和健康对照者之间,整体GI PROMs相似 (p=0.075).
- 在DO患者中,便秘得分明显较低 (p=0.002),表明结果更差;其他领域是相似的. 在DO患者中,患有和没有21型三症的患者显示出相似的PROMs.
结论:
- 经过DO手术后的长期GI PROM与健康个体相比较.
- 在DO患者中便秘的患病率增加,需要有针对性的随访和教育.
- 三胞胎瘤21状态似乎没有显著影响DO患者的长期GI PROM.
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