头癌中的能源消耗:系统性审查和元分析
Lauren Hanna1, Kay Nguo2, Teresa Brown3,4
1Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, VIC, Australia. lauren.hanna@monash.edu.
概括
对头癌 (HNC) 患者来说,准确的能量需求估计至关重要. 这项审查发现,在HNC处理过程中,静止能量消耗 (REE) 是稳定的,并且可以通过小组级预测方程来估计.
科学领域:
- 营养科学 营养科学
- 在瘤学瘤学.
- 代谢过程中的代谢.
背景情况:
- 准确的能源需求估计对于在头癌 (HNC) 中进行有效的营养干预至关重要.
- 对能量需求的预测方程在癌症群体中可能缺乏准确性.
- 本系统性审查综合了对HNC患者测量能量消耗的证据.
研究的目的:
- 系统地审查有关休息能量消耗 (REE) 和总能量消耗 (TEE) 的证据,针对任何阶段的HNC.成年人.
- 将测量的能源消耗与非癌症对照,预测方程和可穿戴设备进行比较.
- 评估HNC处理前后能源消耗的变化.
主要方法:
- 搜索了四个主要的数据库 (Ovid MEDLINE,Embase,CINAHL plus,Cochrane控制试验中央注册表).
- 包括将HNC患者的能量消耗与对照或预测方程进行比较的研究.
- 使用推,评估,开发和评估 (GRADE) 系统对证据的确定性进行评估.
主要成果:
- 11项研究 (n=439) 使用间接热量计测量了REE;没有评估TEE和可穿戴设备.
- 聚合的预处理REE为1502千卡/天.
- 测量的REE略高于预测 (每天110千卡的差异),治疗后降低 (每天-140千卡的差异),但这些变化在组级没有临床意义.
结论:
- 休息能量消耗 (REE) 在整个头癌 (HNC) 治疗过程中相对稳定.
- 预测方程为HNC患者的群体水平的REE提供了合理的估计.
- 建议在HNC研究中增加间接热量计的使用,以准确地确定个人REE,以指导临床实践.
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