乳腺癌后心脏代谢和心血管风险的差异:心脏研究的途径
Andrea E Diaz1, Marilyn L Kwan2, Cecile A Laurent2
1Department of Cardiovascular Disease, University of Washington School of Medicine, Seattle, WA, USA.
JNCI cancer spectrum
|December 17, 2025
概括
患有乳腺癌的种族和少数民族妇女面临更高的心脏代谢风险因素和心血管疾病的风险. 有针对性的心脏瘤干预措施对于解决这些健康差异至关重要.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 健康差异 在健康上的差异
- 流行病学 流行病学
背景情况:
- 心脏代谢风险因素 (CMRF) 和心血管疾病 (CVD) 发病率在乳腺癌 (BC) 妇女代表性不足的种族和民族群体中尚不清楚.
- 了解这些风险对于解决心脏瘤学中的健康差异至关重要.
研究的目的:
- 在被诊断患有BC的种族和种族不同女性中描述CMRF和CVD的发病率.
- 为了比较不同种族和种族群体和非西班牙裔白人 (NHW) 妇女之间的这些风险.
主要方法:
- 对14942名患有侵袭性BC.的女性进行前性队列研究 (Pathways Heart Study).
- 利用电子健康记录来确定CMRF和CVD发生率.
- 雇员竞争风险框架和细灰色回归来估计根据种族/种族的危险比率.
主要成果:
- 与NHW女性相比,黑人和亚洲女性患高血压,糖尿病和脂质失调的风险更高.
- 黑人女性患缺血性心脏病 (IHD),心力衰竭 (HF) 和整体心血管疾病的风险增加.
- 菲律宾妇女的中风风险更高,南亚妇女的IHD和HF风险明显更高.
结论:
- 具有BC的种族和种族多样性的女性经历了糖尿病,高血压和脂质失调的风险增加.
- 特定的子组,包括黑人,亚洲,菲律宾和南亚妇女,面临更高的风险事件心血管疾病.
- 解决心脏瘤学方面的健康差异对于有效预防和治疗心脏病在这个人群中至关重要.
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