母亲微生物群与子的死亡率,杀和后代存活率有关
Iliyass Biada1, María Antonia Santacreu1, Noelia Ibáñez-Escriche1
1Institute for Animal Science and Technology, Universitat Politècnica de València, València, 46022, Spain.
Journal of animal science
|December 17, 2025
概括
子的母体健康和便微生物群预测死亡率和杀风险. 孕产妇微生物群的破坏对后代的生存有负面影响,突出了改善养殖的潜在生物标志物.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 兽医医学 兽医医学 兽医医学
背景情况:
- 在养中的死亡率和杀率显著降低了生产力和利能力.
- 了解影响子命运和后代生存的因素对子产业至关重要.
- 便微生物群的组成越来越被认为是牲畜健康指标.
研究的目的:
- 根据他们未来的健康状况 (死亡,杀或健康) 来调查便微生物群组成的变化.
- 评估微生物群变化与死亡率或杀事件的接近之间的相关性.
- 为了确定母体微生物群的破坏是否会影响后代的存活率.
主要方法:
- 在死亡 (D),生殖除 (CR) 和健康对照 (C) 群体中对动物进行分类.
- 收集软便样本用于V3-V4 16S rRNA基因测序,以分析微生物多样性和组成.
- 开发使用元taxonomic Amplicon Sequence Variants (ASVs) 数据的分类模型来预测命运结果.
主要成果:
- 与健康对照人相比,接近死亡或杀的便微生物丰富度显著降低.
- 分类模型准确地预测了命运结果 (AUC为0.99),当样本收集在事件附近时.
- 母亲的命运显著影响了子的存活率,死者或被杀的后代的存活率降低; 母亲微生物群的组成解释了子存活率的显著变化.
结论:
- 便微生物群的组成可以作为预测子死亡率和生殖杀风险的潜在生物标志物.
- 母亲微生物群的健康与后代的生存密切相关,强调保持其稳定的重要性.
- 这些发现可以为改进的管理实践提供信息,以提高子的福利和生产力.
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