慢性鼻炎中的多微生物生物膜:范围审查
David Broderick1, Kristi Biswas1, Raymond Kim1,2
1Department of Surgery, The University of Auckland, Auckland, New Zealand.
Journal of medical microbiology
|December 17, 2025
概括
生物膜在慢性鼻炎 (CRS) 患者中更常见,可能会加重疾病的严重程度. 虽然有证据表明这些鼻生物膜往往是多微生物,但需要更多的研究来证实这种联系及其临床影响.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 生物膜在慢性鼻炎 (CRS) 中越来越多地被识别出来,这可能解释了治疗耐药性.
- 生物膜的多微生物性质及其与CRS严重程度的相关性仍然不清楚.
研究的目的:
- 对CRS患者中鼻生物膜的流行情况进行范围审查.
- 为了将生物膜的存在与CRS中的临床疾病严重程度相关联.
主要方法:
- 在主要的科学数据库 (PubMed,Scopus,Medline,Web of Science) 进行了全面的文献搜索.
- 在选1853个结果后,包括了39项涉及对CRS患者鼻组织直接可视化生物膜的研究.
主要成果:
- 与对照组相比,CRS患者的生物膜患病率较高.
- 大多数研究表明,生物膜患者的疾病严重程度增加,尽管统计学意义各不相同.
- 九项能够检测多微生物生物膜的研究证实了它们在一小部分病例中的存在.
结论:
- 生物膜在CRS中普遍存在,可能与疾病严重程度的增加有关.
- 有证据表明,鼻生物膜经常是多微生物,需要进一步调查.
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