在化真菌中的生物合成多样性的基于paired-omics的探索和表征
Garima Singh1,2,3, Maonian Xu4, Mitja Zdouc5
1Department of Biology, University of Padova, Via U. Bassi, 58/B, 35121 Padova, Italy.
Microbial genomics
|December 17, 2025
概括
这项研究探讨了形真菌 (LFF) 基因组,发现了数千个新的生物合成基因集群 (BGC). 这些发现凸显了LFF作为新药线索和天然产品的丰富来源.
科学领域:
- 菌类学 菌类学是指菌类学.
- 基因组学就是基因组学.
- 自然产品 化学 化学
背景情况:
- 对非模型生物进行生物勘探对于发现新药线索至关重要.
- 形成性真菌 (LFF) 是生物活性天然产品的丰富生产者,但仍未得到充分利用.
- 比较基因组学和相关基因组学为将自然产品与其生物合成基因集群 (BGCs) 联系提供了有效的方法.
研究的目的:
- 系统地比较菌形成真菌 (LFF) 中的BGC多样性.
- 来自LFF的新生物活性天然产品及其BGC的识别和特征.
- 为了建立一个基线,利用生物合成研究在未研究的真菌种群.
主要方法:
- 从111个公开可用的LFF基因组中进行基因挖掘,以识别BGC.
- 生成BGC相似性网络和基因集群家族.
- 质谱学 (MS) 和相关代谢学来将已识别的代谢物与假定的BGCs联系起来.
主要成果:
- 发现了5541个BGC,分为4464个基因群家族.
- ~98%的已识别的LFF BGC被推测为新型且未具备特征.
- 与核糖体相关的BCG约占LFFBCG景观的20%.
结论:
- 菌形成的真菌拥有广而大部分尚未探索的BGC景观.
- 该研究强调了LFF中许多独特,广泛和以前未被描述的BCC.
- 这项研究为未来在非模型真菌中进行生物合成研究提供了框架,有可能揭示"微生物暗物质".
关键词:
BGCs 是一个BGC.这是一个BIG-SCAPE.国际货币基金基金 (GCF) 是一个全球货币基金组织.亚历克托龙酸 BGC 亚历克托龙酸这是一个反SMASH的方法.生物合成基因生物合成基因遗体已经离开了.德普西多尼 (depsidones) 是一种除剂.埃弗尼克酸 BGC BGC 的意思类的水,类的水.自然产品是自然产品的产品.珀拉托利克酸 BGC 的含量二次新陈代谢二次新陈代谢石酸 BGC 石酸 BGC 石酸 BGC更多相关视频
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