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一种纤维包裹,将先进的纳米微混合结构与有效的药物输送相结合,以加速伤口愈合

Qi Meng¹, Chenyu Li², Jiayi Jiang¹

¹College of Textiles & Clothing, Qingdao University, Qingdao 266071, China.

ACS applied bio materials

|December 17, 2025

概括

结合氧化 (ZnO) 和复星 (Res) 的新纤维包裹可显著加快伤口愈合. 这些纳米微结合纤维包裹 (NCFD) 具有高抗菌活性,通过减少炎症来促进组织再生.

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
伤口治愈研究研究伤口治愈研究

背景情况:

有效的伤口愈合需要带有先进的物理和生物线索的带.
目前的治疗方法往往无法充分解决感染,炎症和组织再生的问题.
纳米微结合纤维包裹 (NCFD) 为整合多种治疗功能提供了一个有前途的平台.

研究的目的:

开发和评估包含氧化 (ZnO) 和复星 (Res) 的新型纳米微结合纤维料 (NCFD).
评估这些NCFD的抗菌,生物相容性,静血和伤口愈合能力.
为了研究ZnO和Res加载的NCFDs对巨细胞极化和炎症的影响.

主要方法:

使用与聚烯酸 (PCL) 微纤维和纳米纤维的结合电制造NCFD的制造.
将氧化 (ZnO) 纳米颗粒和复星 (Res) 纳入纤维结构.
在体外评估抗细菌活性对抗大肠杆菌和黄金葡萄球菌,以及与人类皮肤纤维细胞 (HDF) 的生物相容性.
在小鼠肝脏出血模型中的静血性能和伤口愈合效率的体内评估.
对再生组织进行对原沉积,上皮再生,新血管化和巨细胞极化 (M2表型) 的分析.

主要成果:

装有ZnO的NCFD显示了99%以上的抗菌效果,对大肠杆菌和黄金色杆菌有抗菌作用.
所有NCFD都表现出极好的生物相容性和优越的血静性质.
mPCL + 0.5%ZnO/nPCL + 8%Res NCFD在10天内实现了93.7%的伤口关闭,增强了原,表皮化和血管化.
这些NCFD显著促进了M2巨细胞的两极分化,减少了局部炎症.

结论:

开发的mPCL + ZnO/nPCL + Res NCFD具有独特的结构,具有强大的抗菌和治疗功能.
这些NCFD通过增强组织再生和调节免疫反应,显著加速伤口愈合.
这项研究提出了一种创新的方法,用于创建先进的伤口包裹,在皮肤组织工程和临床应用中具有巨大的潜力.

关键词:

复合材料的连衣,可以使用.结合式电线的电线.药物输送是药物输送的过程.混合结构混合结构混合结构治疗伤口的治疗方法

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