一个简单的在线内部标准校准策略,用于基于多元元素分析的单粒子诱导合等离子体质谱
Xiangwei Tian1,2,3,4, Ying Wang1, Peijie Yang2,3
1School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Analytical chemistry
|December 17, 2025
概括
单粒子感应合等离子体质谱法 (SP-ICP-MS) 中的矩阵效应可能导致纳米粒子大小测量不准确. 使用非分析物元素的新在线校准方法纠正了这些影响,提高了复杂样品的准确性.
科学领域:
- 分析化学 分析化学
- 环境科学 环境科学
- 纳米技术 纳米技术
背景情况:
- 单粒子感应合等离子体质谱 (SP-ICP-MS) 对于分析粒子异质性至关重要.
- 环境和生物样本中的矩阵效应显著阻碍了SP-ICP-MS的精确质量/尺寸测定.
研究的目的:
- 为了研究对SP-ICP-MS分析阶段的矩阵效应.
- 开发和验证一种新的在线内部标准校准策略,用于在复杂矩阵中准确量化纳米粒子.
主要方法:
- 系统地调查对SP-ICP-MS的矩阵效应.
- 开发在线内部标准校准策略,使用多元检测和非分析元件 (如Pd,Au) 作为内部标准.
- 拟议的校准方法的实验验证.
主要成果:
- 由于30-50%的信号衰减,矩阵效应导致Ag纳米粒子尺寸低估了~10nm.
- 新的校准策略有效地纠正了矩阵诱导的信号变化和雾化效率.
- 使用新方法优化的SP-ICP-MS在模拟和真实样本中实现了测量和真实颗粒大小之间的良好一致.
结论:
- 拟议的在线内部标准校准方法为SP-ICP-MS提供了可靠和灵活的解决方案.
- 这种方法提高了SP-ICP-MS在复杂的环境和生物样本中分析纳米粒子的适用性.
- 精确的纳米粒子表征现在在具有挑战性的样本矩阵中更加可行.
相关概念视频
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview
1.7K
In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
1.7K
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences
1.2K
Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
1.2K
Atomic Emission Spectroscopy: Lab
538
AES is a powerful analytical technique, especially effective when used with plasma sources, producing abundant spectra in characteristic emission lines. The Inductively Coupled Plasma (ICP), in particular, yields superior quantitative analytical data due to its high stability, low noise, low background, and minimal interferences under optimal experimental conditions. However, newer air-operated microwave sources are emerging as promising alternatives that could be more cost-effective than...
538
Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle
1.6K
Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
1.6K
Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation
612
Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....
There are three main types of inductively coupled plasma atomic emission spectroscopy (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....
612
Mass Analyzers: Common Types
1.3K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
1.3K


