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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA LINC-PINT 控制淋巴功能和淋巴水的炎症概况.

Nathalie Laugero1, Claire Peghaire1, Léna Verdu1

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长跨基因非蛋白编码RNA (LINC-PINT) 对于淋巴发育至关重要. 它在淋巴内皮细胞中的缺乏减少了小鼠淋巴的严重程度和炎症.

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科学领域:

  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.
  • 免疫学 免疫学 免疫学

背景情况:

  • 淋巴水是一种慢性疾病,由淋巴系统功能障碍引起.
  • 二次淋巴,通常是由癌症治疗引起的,显著影响患者的生活质量.
  • 非编码RNA在细胞过程中起着关键作用,但它们在淋巴的具体参与尚未完全理解.

研究的目的:

  • 研究非编码RNAs在乳腺癌诱导的二次淋巴的作用.
  • 为了确定特定的长非编码RNAs (lncRNAs) 参与淋巴瘤发病.
  • 阐明已识别的 lncRNAs 调节淋巴功能的分子机制.

主要方法:

  • 人类淋巴瘤样本的非编码RNA分析.
  • 在淋巴内皮细胞 (LECs) 中LINC-PINT的淘汰.
  • ATAC-seq来评估染色体的可访问性.
  • 在小鼠淋巴内皮中条件删除LINC-PINT (Lnc-Pintlecko).

主要成果:

  • 确定LINC-PINT是人类LECs中表达最多的lncRNA,对于淋巴发育至关重要.
  • 在LECs中LINC-PINT敲除增加了与炎症相关的基因表达.
  • LINC-PINT 增强了染色质的可访问性,促进了参与淋巴血管生成和免疫细胞粘附的基因的转录.
  • 由于LINC-PINT缺陷,LEC的增殖,迁移和发芽都受到影响.
  • 在Lnc-Pintlecko小鼠中,淋巴,皮肤回流,纤维化和炎症的减少.

结论:

  • LINC-PINT在淋巴内皮细胞功能和淋巴病原发生过程中起着至关重要的作用.
  • 通过染色体重塑,LINC-PINT调节淋巴血管生成和免疫反应.
  • LINC-PINT 是一种潜在的治疗标,也是淋巴瘤的有价值生物标志物.