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Updated: Jan 8, 2026

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SLFN14作为P-TEFb抑制剂起作用,调节HIV-1和细胞基因的转录

Shu-Min Chen1,2, Ling Ma1, Zhen Wang3

  • 1Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, China.

Science advances
|December 17, 2025
PubMed
概括

施拉芬14 (SLFN14) 通过阻断正转录延长因子b (P-TEFb) 复合体来抑制HIV-1复制. 这一发现揭示了SLFN14的存在.

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Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
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