结石与未来癌风险之间的关联:系统性审查和元分析
Naeem Bhojani1, Larry E Miller2, Samir Bhattacharyya3
1Division of Urology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
概括
患有结石病史的人面临患癌的风险显著增加. 这一元分析证实了近两倍的高风险,强调了需要加强石形成者的癌症监测.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 结石和癌之间的关系尚未完全理解.
- 这项研究调查了结石病史与随后患癌的风险之间的关联.
研究的目的:
- 系统地审查和分析评估结石史和细胞癌 (RCC) 风险的观察性研究.
- 量化结石与未来癌发展之间的关联.
主要方法:
- 在Medline,Embase和Cochrane中央注册的系统文献搜索.
- 包括成人细胞癌风险在患有结石的患者的观察性研究.
- 随机效应元分析用于计算聚合风险比率和置信区间 (CI),使用子组分析和元回归.
主要成果:
- 包括13项研究 (5个队列,8个病例控制).
- 患有结石的病史与患癌的更高风险有显著的关联 (风险比率2.36;95% CI 1.74-2.98).
- 在各个子组中观察到持续升高的风险,在最近的研究中更强烈的关联.
结论:
- 石病史与患癌的风险大大增加有关,大约使风险增加了一倍.
- 强调加强对患有结石的患者进行癌症监测的重要性.
- 建议进一步研究结石和癌的共享机制和预防策略.
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