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集成到芯片器官设备中的传感器系统:从检测到制造

Gabriel M Ferreira^1,2, Patrícia C Sousa², Susana O Catarino^1,3

¹Microelectromechanical Systems Research unit (CMEMS-UMinho), School of Engineering, Campus de Azurém, University of Minho, Guimarães, 4800-058, Portugal.

Small (Weinheim an der Bergstrasse, Germany)

|December 17, 2025

概括

器官芯片 (OoC) 设备通过模仿人类生理学,为药物测试提供了一个有希望的替代方案. 集成各种传感器实时监测细胞反应仍然是这些先进的微流体系统的关键挑战.

科学领域:

生物技术是生物技术.
微流体学微流体学
组织工程是组织工程.

背景情况:

器官在芯片 (OoC) 设备利用微流体系统在微观尺度上复制人类生理功能.
微型制造和组织工程的进步使OOCs能够培养细胞并以可复制性和低成本重建生化/机械刺激.
在临床前药物药物测试和疗效预测方面,OOCs是一个有希望的替代品.

研究的目的:

审查器官芯片设备实时监控的传导技术.
探索当前的战略,局限性,以及将传感器集成到OOC平台中的潜在解决方案.
通过改进细胞响应监测,提高预测药物疗效的准确性.

主要方法:

探索各种传导技术,包括光学,电化学,机械和电阻传感器.
在单个OOC平台内对多种传感器类型的当前集成策略的分析.
审查微型制造技术,如基于洁净室的方法和3D打印.

主要成果:

确定各种传感器的有效集成用于实时监控是OOC开发的一个重大挑战.
突出了OOCs通过精确监测细胞反应来预测药物疗效的潜力.
讨论了与当前传导集成方法相关的局限性.

结论:

多种转导技术的有效整合对于推进芯片器官技术至关重要.
解决目前的局限性将提高OOCs在药物开发和临床前测试中的可靠性.
未来的战略应侧重于无传感器集成,以在功能性器官模型中进行全面的实时监控.

关键词:

整合整合整合整合微型制造是指微型制造.器官在芯片上的器官传感器传感器传感器

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