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集成的转录基因和蛋白质基因洞察力,以适应低盐度压力在Penaeus monodon

Hongshan Diao¹, Jianzhi Shi², Song Jiang³

¹College of Aqua-life Science and Technology, Shanghai Ocean University, Shanghai, China; Key Laboratory of South China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture and Rural Affairs, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China.

Comparative biochemistry and physiology. Part D, Genomics & proteomics

|December 17, 2025

概括

鱼 (Penaeus monodon) 通过随着时间的推移改变能量代谢和免疫反应来适应低盐度. 这项研究揭示了养殖中抗压力的动态分子策略.

科学领域:

* 水产养殖和甲动物生物学
*环境压力生理学 *环境压力生理学
* 分子适应机制

背景情况:

*由于气候变化,盐度波动对Penaeus monodon水产养殖造成重大威胁.
*对类适应低盐度环境的分子基础的理解有限.
* 需要采用多学科方法来阐明复杂的应激反应.

研究的目的:

* 在低盐度压力下系统研究Penaeus monodon的分子调节机制.
*分析不同时间点 (6小时,24小时,96小时) 的转录组和蛋白组变化.
* 提供一个全面的多学科地图库,描述P. monodon. 低盐度适应的情况.

主要方法:

*转录组分析以确定差异表达基因 (DEGs).
*蛋白质组分析以确定差异表达蛋白 (DEP).
*整合转录组和蛋白组数据,用于协调监管模式分析.

主要成果:

* 在低盐度压力下识别了927个DEG和928个DEP.
*观察到动态适应策略:初始免疫抑制和补偿通路激活 (6小时),增强代谢活动 (24小时) 和持续的能量代谢与排毒系统激活 (96小时).
*通过多omics集成发现了协调的基因-蛋白调节模式.

结论:

* 介绍了第一个详细介绍P. monodon对低盐度的时间解决反应的多学科地图.
* 提供了关于甲动物透调节和分子适应的新见解.
* 确定了有价值的分子标,用于培育耐盐的P. monodon菌株,支持可持续的水产养殖.

关键词:

适应机制适应机制综合分析综合分析盐度低,盐度低,盐度低,盐度低,盐度低,盐度低.多个omics的多个omics.佩内乌斯单一鱼 (Penaeus monodon) 是一个单一鱼.

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