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铁:女性生殖健康的双刃剑

Rui Mao¹, Dan Yin¹, Wenbo Lv¹

¹Department of Cell Biology and Genetics, Institute of Cytology and Genetics, School of Basic Medical Sciences, Hengyang Medical School, Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, Key Laboratory of Hengyang City on Biological Toxicology and Ecological Restoration, Key Laboratory of Typical Environmental Pollution and Health Hazards, University of South China, Hengyang, Hunan 421001, PR China.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

|December 17, 2025

概括

缺铁和超负荷影响女性生殖和怀孕结果. 了解铁的含义了解铁的含义

科学领域:

生殖生物学生殖生物学
营养科学营养科学
细胞生物学细胞生物学

背景情况:

铁对人类的新陈代谢和生理功能至关重要.
铁水平的不平衡,包括缺乏和过载,显著影响女性生殖健康.
反应性氧物种 (ROS) 和脂质过氧化与铁诱导的细胞损伤有关.

研究的目的:

审查铁缺乏和过载对女性生殖的多方面的影响.
探索铁亡的作用,一种依赖铁的细胞死亡,在女性生殖系统疾病中.
为治疗与铁有关的女性生殖障碍提供见解.

主要方法:

关于铁代谢和女性生殖健康现有研究的文献综述.
分析铁缺乏和超负荷背后的机制.
检查铁和妇科疾病之间的联系.

主要成果:

缺铁和过重负荷会对孕妇,胎儿发育和胎盘功能产生不利影响.
过量的铁会诱导ROS和脂质过氧化,损害女性生殖组织.
铁亡与多囊性卵巢综合征,子宫内膜异位症,子宫内膜癌,卵巢癌和过早的卵巢衰竭有关,有助于不孕.

结论:

铁平衡对于维持女性生殖健康至关重要.
铁死呈现了一种新的机制,将铁过载与各种生殖疾病和不孕症联系起来.
对铁亡机制的进一步研究可以指导女性生殖障碍的治疗策略.

关键词:

女性生殖系统疾病女性生殖系统疾病铁化是铁化的一种.铁的代谢铁的代谢脂质过氧化过氧化有反应性氧物种的反应性氧物种.

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