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开发一种空气采样方法,用OSHA多功能采样器 (OVS) 管量化12种传统和新兴的PFAS,并通过HPLC-MS/MS进行分析

Wael H Abdelraheem¹, Jennifer L Roberts¹, Kristine S Kurtz²

¹Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Chemical and Biological Monitoring Branch, 1090 Tusculum Ave, Cincinnati, Ohio, 45226, United States.

|December 17, 2025

概括

这项研究验证了OSHA多功能采样器 (OVS) 管用于监测工作场所空气中更广泛的和多基物质 (PFAS). OVS管有效捕获各种PFAS,有助于评估职业暴露和减轻健康风险.

科学领域:

环境化学环境化学
职业健康和安全问题职业健康和安全问题
分析化学分析化学

背景情况:

和多基基物质 (PFAS) 是常见的环境污染物,具有已知的健康风险.
现有的空气采样方法往往缺乏量化传统和新兴PFAS的广泛范围的能力.
欧沙多功能采样器 (OVS) 管是一种广泛用于空气采样的设备,但其用于各种PFAS的应用需要评估.

研究的目的:

评估OSHA多功能采样器 (OVS) 管用于量化空气中12种遗留和新出现的和多醇基物质 (PFAS) 的有效性.
扩大OVS管的分析范围,超越传统的化合物,如 perfluorooctanoic 酸 (PFOA),包括各种 perfluorocarboxylic 酸 (PFCA), perfluorosulfonic 酸 (PFSA),HFPO-DA (GenX) 和 DONA-Na.
建立一种可靠的空气采样方法,用于监测职业接触广泛的PFAS.

主要方法:

开发了一种两步增方法,将非挥发性 (PFSAs,DONA-Na) 和半挥发性 (PFCAs,HFPO-DA) PFAS引入OVS管介质.
使用高性能液体染色学-并联质谱法 (HPLC-MS/MS) 来量化PFAS.
方法验证包括评估提取效率,分析检测极限 (LODs),以及在23°C的28天储存期内回收和突破分析物.

主要成果:

对于OVS媒体提取的平均恢复率在97.1%至100.1%之间.
尖的PFAS化合物在28天内有效地保留在OVS管上,平均恢复率在91%至103%之间,所有分析物的突破率低于5%.
确定了分析检测极限 (LOD),使得空气样本中目标PFAS的敏感量化成为可能.

结论:

OVS管被认证为可靠的空气采样装置,用于监测职业环境中更广泛的传统和新兴PFAS.
该方法为准确的健康风险评估和工作场所有效的暴露减轻策略提供了至关重要的支持.
OVS管的扩展能力提高了对PFAS的环境监测和监管合规性.

关键词:

空气采样采样空气采样环境监测环境监测环境监测风险投资评估风险投资评估在HPLC-MS/MS中使用.在OSHA的多功能采样器.在PFAS中,有很多方法.

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