2型糖尿病老年人的日间皮质醇循环和认知表现
Lorena Vallejo1, Mariola Zapater-Fajarí2, Teresa Montoliu1
1Laboratory of Cognitive Social Neuroscience, Department of Psychobiology and IDOCAL, University of Valencia, Valencia, Spain.
Psychoneuroendocrinology
|December 17, 2025
概括
与对照人群相比,患有2型糖尿病 (T2D) 的老年人表现出认知缺陷,特别是在记忆和执行功能方面. 然而,下丘脑-垂体-上腺 (HPA) 轴的皮质醇模式无法解释这些差异.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 2型糖尿病 (T2D) 与下丘脑-垂体-上腺 (HPA) 轴失调和老年人认知障碍有关.
- 在T2D人口中,HPA轴功能在认知缺陷中的特定作用仍未得到充分研究.
研究的目的:
- 为了比较T2D和健康对照的老年人之间的白天皮质醇模式和认知表现.
- 研究皮质醇指数 (皮质醇唤醒反应[CAR]和白天皮质醇斜率[DCS]) 与认知功能 (声明记忆[DM],工作记忆[WM],执行功能[EF]) 之间的关联.
主要方法:
- 通过认知测试和贝克抑郁 inventory (BDI-II) 对51名T2D患者和51名健康对照进行了比较.
- 评估CAR和DCS使用两周两天的每天四次唾液样本.
- 进行了群体比较和调节分析,包括抑郁症作为调节者.
主要成果:
- 与对照组相比,T2D患者在DM和WM中表现较差.
- 在T2D组和对照组之间没有发现CAR或DCS的显著差异.
- 皮质醇指数与认知表现的关联有限,在整个样本中只在特定的抑郁水平上观察到一些相关性.
结论:
- 医疗治疗的T2D患者表现出认知缺陷,但HPA轴皮质醇模式似乎不是主要的贡献因素.
- 需要进一步的研究来探索其他影响T2D老年人认知功能的机制和抑郁症的作用.
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