自闭症和荷尔蒙:从免疫系统和肠道微生物组的角度来看
Charles Veilleux1, Emine Defne Erenben1, Nafissa Ismail2
1School of Psychology, University of Ottawa, 136 Jean-Jacques Lussier, Ontario, K1N 6N5, Canada.
Hormones and behavior
|December 17, 2025
概括
自闭症谱系障碍 (ASD) 在全球影响2.7%. 本综述探讨了荷尔蒙失衡,免疫激活和肠道失调作为ASD发展的关键因素及其在男性中更高的患病率.
科学领域:
- 神经发育障碍 神经发育障碍
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 微生物学 微生物学
背景情况:
- 自闭症谱系障碍 (ASD) 影响全球2.7%的人口,其特点是社会和沟通缺陷.
- 自闭症发病发生在生命的早期,在男性中更频繁地被诊断出来,尽管潜在的机制仍然不清楚.
研究的目的:
- 审查导致ASD发展的因素的复杂相互作用.
- 阐明自闭症发病背后的机制及其在男性中更高的患病率.
主要方法:
- 关于荷尔蒙失衡的文献综述.
- 免疫系统激活的分析 (母体和新生儿免疫激活).
- 检查ASD发展中的免疫失调和肠道失调.
主要成果:
- 荷尔蒙失衡与自闭症发展有关.
- 产前和新生儿免疫激活在ASD中发挥作用.
- 免疫失调和肠道失调与ASD有关.
结论:
- 多种相互作用的系统,包括荷尔蒙,免疫和肠道微生物群,有助于ASD.
- 这些相互作用的复杂性强调了ASD的多方面的性质.
- 需要进一步的研究来澄清驱动自闭症和性别差异的确切机制.
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