Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein-protein Interfaces02:04

Protein-protein Interfaces

14.4K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Comparative study on the diversity and abundance of bacterial composition in four non-biting synanthropic flies from The Gambia and China.

BMC veterinary research·2026
Same author

A VOC-centric web of biological interaction on corpse: Consideration for forensic PMI estimation.

iScience·2026
Same author

Medium- and Large-sized Mammals on the Plateau: An Evolutionary Crucible for Zoonotic Pathogens - Ecological Drivers, Adaptive Evolution, and One Health Control.

Microbial ecology·2026
Same author

Olfactory gene profiling in ticks: A scoping review with a functional perspective.

Veterinary and animal science·2026
Same author

Wings on concealed corpse: the forensic importance of scuttle flies (Diptera: Phoridae).

Frontiers in insect science·2026
Same author

Distribution of <i>Rhipicephalus microplus</i> and <i>Hyalomma lusitanicum,</i> and the pathogens they are carrying: A systematic review.

Parasite epidemiology and control·2025

相关实验视频

Updated: Jan 8, 2026

A Calcium Bioluminescence Assay for Functional Analysis of Mosquito Aedes aegypti and Tick Rhipicephalus microplus G Protein-coupled Receptors
10:46

A Calcium Bioluminescence Assay for Functional Analysis of Mosquito Aedes aegypti and Tick Rhipicephalus microplus G Protein-coupled Receptors

Published on: April 20, 2011

16.0K

通过分子对接和动力学模拟来研究Rhipicephalus microplus中微类蛋白质的嗅觉功能.

Afito Luciano1, Yuxin Huo1, Sha Tan1

  • 1School of Basic Medical Sciences, Central South University, Changsha 410013, China.

Veterinary parasitology
|December 17, 2025
PubMed
概括

这项研究表明,中的微类蛋白 (MLP) 可以检测挥发性有机化合物,尿酸显示出更大的稳定性. 这一发现可能会导致新的控制策略.

关键词:
化学传感器是一种化学传感器.微类蛋白质是一种类似于微类蛋白质的蛋白质.分子对接是分子对接.分子动力学模拟的模拟.里皮塞法卢斯 (Rhipicephalus microplus) 是一个微型.挥发性有机化合物 挥发性有机化合物

更多相关视频

Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
05:50

Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro

Published on: September 26, 2025

1.4K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

898

相关实验视频

Last Updated: Jan 8, 2026

A Calcium Bioluminescence Assay for Functional Analysis of Mosquito Aedes aegypti and Tick Rhipicephalus microplus G Protein-coupled Receptors
10:46

A Calcium Bioluminescence Assay for Functional Analysis of Mosquito Aedes aegypti and Tick Rhipicephalus microplus G Protein-coupled Receptors

Published on: April 20, 2011

16.0K
Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
05:50

Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro

Published on: September 26, 2025

1.4K
Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

898

科学领域:

  • * 昆虫学 昆虫学
  • * 分子生物学 * 分子生物学
  • * 生物化学 * 生物化学

背景情况:

  • *会传播许多病原体,对公众健康和动物健康构成重大风险.
  • * 化学感知知觉对于虫寻找宿主行为和疾病传播至关重要.
  • * 了解的嗅觉机制可以为新的控制策略提供信息.

研究的目的:

  • * 调查Rhipicephalus microplus微类蛋白 (MLP) 在检测挥发性有机化合物 (VOC) 的功能.
  • * 为了确定与MLP相互作用的特定VOC.
  • * 评估MLP-VOC复合物的稳定性和结构动态.

主要方法:

  • *使用AlphaFold2,瑞士模型和AlphaFold3.3进行蛋白质结构预测.
  • *使用AutoDock Vina和发现工作室可视化器进行分子对接模拟.
  • *使用GROMACS的分子动力学模拟.
  • *分析蛋白质-VOC相互作用,包括结合能量和稳定性.

主要成果:

  • *四种挥发性有机化合物对MLP显著结合:斯夸伦,尿酸,β-离子子和2,4-Di-tert-butylphenol.
  • *在分子动力学模拟中,尿酸与MLP的结合稳定性比素更强.
  • * 尿酸-MLP复合体显示较低的RMSD,一致的键和稳定的构造趋同.
  • * 斯夸伦-MLP复合物表现出更高的构造变异性,缺乏稳定的键.

结论:

  • * 微类蛋白 (MLP) 在识别中的挥发性有机化合物方面发挥作用.
  • *尿酸是MLP的潜在连接体,在复杂形成中表现出高稳定性.
  • *这些发现为开发创新,有针对性的控制方法提供了洞察力.