身体活动通过减轻与免疫发生相关的炎症和改善整体免疫力来降低癌症负担
Yi Jin1, Zhiyu Yang2, Zishuai Li1
1Department of Epidemiology, Second Military Medical University, Shanghai 200433, China; Key Laboratory of Biological Defense, Ministry of Education, Second Military Medical University, Shanghai 200433, China; Shanghai Key Laboratory of Medical Bioprotection, Second Military Medical University, Shanghai 200433, China.
Cell reports. Medicine
|December 17, 2025
概括
定期体育活动 (PA) 通过减少炎症和改善免疫力来降低癌症风险. 特别是有氧运动,与炎症相关癌症和死亡率的风险降低有关,特别是在老年人中.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 运动科学 运动科学
背景情况:
- 身体活动 (PA) 与癌症发病率/死亡率以及其机制之间的关系尚未完全理解.
- 系统性炎症随着年龄的增长而增加,并与某些癌症和整体死亡率的风险增加有关.
研究的目的:
- 研究身体活动,全身炎症和癌症风险之间的剂量依赖关系.
- 阐明运动可以降低癌症风险的免疫调节机制.
主要方法:
- 来自英国和美国的大型队列研究 (443,768名成年人) 的分析.
- 在动物模型 (老鼠和仓鼠) 中利用单细胞测序,RNA测序,细胞测量和炎症阵列.
主要成果:
- 身体活动显示出与较低的全身炎症水平存在剂量依赖的关联.
- 有氧体力活动 (每周117-500分钟) 与炎症相关癌症风险降低和所有癌症死亡率显著相关.
- 运动训练降低了免疫发生标志物和促炎因素的调节,同时提高了抗炎因素和关键免疫细胞的调节.
结论:
- 身体活动,特别是有氧运动,通过减轻炎症和免疫衰变,降低癌症风险.
- 运动改善免疫功能,有助于预防癌症,特别是在老年人群中.
- 研究结果确定了运动,炎症调节和减少癌症风险之间的机制联系.
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