生物衰老与中风和全因死亡率之间的关联:基于人口的横截面研究和孟德尔随机化分析
Zijie Wang1, Xinwei Zhao1, Yan Ma1
1The Second Affiliated Hospital Of Tianjin University Of TCM, Tianjin, 300143, China.
概括
生物衰老指标,包括脆弱指数 (FI),与增加中风风险和死亡率有关. 该FI显示出最强的关联,表明其在中风风险评估和预防策略中的实用性.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 脑卒中是导致死亡和残疾的主要原因,老龄化是主要的危险因素.
- 个体的脑血管脆弱性在时间上有很大的差异,尽管年龄.
- 这项研究探讨了生物衰老标志物与中风风险/预后之间的联系.
研究的目的:
- 调查生物衰老指标与中风患病率之间的关联.
- 评估生物衰老对中风幸存者的全因死亡率的影响.
- 使用孟德尔随机化检查生物衰老和中风之间的潜在因果关系.
主要方法:
- 利用NHANES数据 (1999-2018) 来计算脆弱指数 (FI),克莱梅拉-杜巴尔年龄 (KDMAge) 和表型年龄 (PhenoAge).
- 使用后勤回归,生存分析 (卡普兰-梅尔,考克斯回归) 和双向孟德尔随机化 (MR).
- 使用大型全基因组关联研究评估了与中风患病率,死亡率和潜在因果关系的关联.
主要成果:
- 更高的FI,KDMAge和PhenoAge与中风风险增加相关.
- 在中风患者中,PhenoAge加速和脆弱状态预测了降低生存率和更高的死亡率.
- 基因预测FI与整体中风风险和缺血性亚型有着强烈的关联;中风责任也与加速衰老有关.
结论:
- 多种生物衰老指标与中风风险和死亡率有关.
- 脆弱指数 (FI) 成为中风风险和存活率的强有力的预测指标.
- 这些发现支持FI作为中风风险分层和二次预防的工具的潜力.
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