门德尔随机化分析揭示了白质微观结构与腹腔大动脉瘤风险之间的关系
Liren Duan1, Shenli Li2, Qi Yan3
1Department of Vascular Surgery, The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention and Therapeutics of Aortic Aneurysm, Shenyang, Liaoning Province, China.
Ageing research reviews
|December 17, 2025
概括
白质微观结构 (WMM) 的变化因果影响腹腔大动脉瘤 (AAA) 风险. 在特定的大脑区域的较低分数异质性会增加AAA风险,而AAA似乎不会影响WMM.
科学领域:
- 神经成像遗传学 神经成像遗传学
- 心血管研究研究心血管研究
- 门德尔的随机化 门德尔的随机化
背景情况:
- 新兴研究表明,白质微观结构 (WMM) 和腹腔大动脉动脉瘤 (AAA) 之间存在联系.
- 对于WMM和AAA之间的因果关系,需要使用可靠的方法进一步调查.
研究的目的:
- 使用双向门德尔随机化 (MR) 框架调查WMM和AAA之间的因果关系.
- 为了确定WMM的变化是否会增加发展AAA的风险.
- 评估AAA是否影响WMM的完整性.
主要方法:
- 利用AAA的全基因组关联研究 (GWAS) 数据 (39,221例,1,086,107例对照) 和WMM的扩散张力成像指标 (43,802名欧洲参与者).
- 采用双向MR设计,包括IVW回归,MR-Egger和加权中位数在内的灵敏度分析.
- 来自AAAgen联盟和大脑成像遗传学知识门户网站 (BIG-KP) 的数据.
主要成果:
- 环 (海马体) 中平均分数异构性 (FA) 的降低与AAA风险显著增加有关 (OR 1.266,P=8.28×10−5).
- 在内部囊的逆部分的下方FA也增加了AAA风险 (OR1.196,P=1.82×10−4).
- 反向因果关系分析显示,AAA和WMM变化之间没有显著的关联.
结论:
- 双向MR分析证实了WMM改变对AAA发展的因果关系.
- WMM的完整性是影响腹腔大动脉动脉瘤发展风险的重要因素.
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