区分弹性和易感性:在学习恐惧时的大脑网络的改变,以应对童年的不可预测性
Xinyu Cao1, Shanshan Wang1, Junhui Zhang1
1Center for Early Environment and Brain Development, School of Education, Guangzhou University, Guangzhou, China; School of Education, Guangzhou University, Guangzhou, China.
Progress in neuro-psychopharmacology & biological psychiatry
|December 17, 2025
概括
童年的不可预测性会以不同的方式影响大脑网络. 弹性个体显示较少的全球网络和独特的连接模式,有助于早期识别脆弱性和有针对性的干预措施.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 网络科学 网络科学
背景情况:
- 儿童时期的不可预测性是精神病理学的危险因素.
- 然而,并非所有暴露在逆境中的个人都会发展出心理健康问题.
- 确定神经性机制至关重要.
研究的目的:
- 识别神经网络的特征,区分弹性从易受心理病理学后的童年不可预测性.
- 探索功能性大脑连接在适应性和不适应性反应中对早期生活逆境的作用.
主要方法:
- 在恐惧学习任务中从213名参与者获得fMRI数据.
- 构建了全脑功能连接网络.
- 利用图形理论和基于网络的统计数据,使用双重弹性指标 (心理和生物).
主要成果:
- 弹性个体表现出较少的全球网络结构.
- 易受感染的个体在特定的大脑区域的节点中心性增加.
- 弹性组显示出更强的DMN连接与前端对象和注意力网络;敏感组显示出DMN,DAN,FPN和VN之间的连接变化.
结论:
- 儿童时期的不可预测性与大脑连接体组织的明显变化有关.
- 神经网络连接模式可以高准确度 (89%) 预测弹性或易感性.
- 这些发现提供了神经生物学标记,用于早期发现脆弱性和开发干预措施.
相关概念视频
Preparedness and Phobias
301
Human fear responses to certain stimuli, such as darkness, heights, deep water, and blood, can often arise despite the absence of direct negative experiences. This phenomenon is rooted in evolutionary psychology, which posits that humans have developed a predisposition to fear stimuli that historically posed significant survival threats. This predisposition, known as preparedness, suggests that early humans who developed a fear of potentially dangerous entities, such as venomous snakes and...
301
Avoidance Learning and Learned Helplessness
2.5K
Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
2.5K
Neuroplasticity
1.5K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
1.5K
Socioemotional Development during Infancy
406
Socio-emotional development in infancy is primarily shaped by early emotional responses and social connections, with temperament playing a central role. Temperament refers to the consistent patterns in an individual's emotional and behavioral responses, observable even in infancy. By examining temperament, researchers can better understand an infant's unique ways of interacting with the world, influencing subsequent personality and socio-emotional growth.
Primary Temperament Types
Primary Temperament Types
406
Attachment Styles
276
Jeffrey Simpson's attachment theory suggests that early caregiver relationships shape lasting patterns of behavior and emotional regulation, known as attachment styles. These patterns are organized along two key dimensions: self-esteem and interpersonal trust. The intersection of these dimensions produces four primary attachment styles that typically persist throughout life and significantly influence how individuals form and maintain relationships.Secure Attachment StyleIndividuals with a...
276
Functional Brain Systems: Limbic System
6.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
6.3K


