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孕产妇的免疫炎症标志物调解尿甲酸代谢产物和产前症之间的关联

Lin Tao¹, Lulu Dai², Shimin Xiong²

¹Centre for Disease Control and Prevention, Huaxi District, Guiyang, Guizhou 550025, China; Key Laboratory of Maternal and Child Health and Exposure Science, Guizhou Provincial Department of Education, Zunyi, Guizhou 563000, China; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China.

Environmental toxicology and pharmacology

|December 17, 2025

概括

孕妇在怀孕期间接触甲酸盐 (PAE) 与更高的孕前风险有关. 免疫-炎症标志物部分调解了这种关联,突出了潜在的不良妊娠结果机制.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
免疫学免疫学免疫学

背景情况:

在怀孕期间调查母亲免疫炎症标志物和尿甲酸盐 (PAE) 代谢物之间的联系.
专注于与妊娠前和其他不良生殖结果的潜在关联.

研究的目的:

综合研究母体免疫炎症标志物与尿路PAE代谢物之间的关联.
探索免疫-炎症标志物的调解作用在PAE暴露和孕前之间的关系.

主要方法:

采用了一个与倾向分数相匹配的病例对照设计 (61例,118例对照).
采用了后勤回归,受限立方线 (RCS),贝叶斯内核机器回归 (BKMR) 和结构方程建模 (SEM).

主要成果:

在孕前炎症病例中观察到尿中PAE代谢物 (MEHP,MEHHP) 和全身免疫炎症指数 (SII) 的升高.
在MEHP,MOP,MEHHP,SII和产前之间发现了积极的关联.
免疫-炎症标志物 (SII,AISI,MLR,PLR) 部分介导了PAE代谢物和子宫前之间的关系.

结论:

母亲尿液PAE代谢物与先兆子的风险增加有关.
免疫-炎症标记在这种关联中起着部分调解作用.
这些发现提供了关于将产前PAE暴露与不良妊娠结果联系在一起的机制的见解.

关键词:

免疫-炎症指数的指数调解分析调解分析甲酸是一种酸盐.孕前症孕前症

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