在过去的10万年里,人类口腔的进化
Rosa Herbst1, Anan Ibrahim1, Alexander Hübner2,3
1Department of Paleobiotechnology, Leibniz Institute for Natural Product Research and Infection Biology─Hans Knöll Institute, 07745 Jena, Germany.
Journal of the American Chemical Society
|December 17, 2025
概括
研究人员探索古老的口腔微生物以发现新的抗微生物 (AMP) 或细菌素, 揭示了在10万年内保持活性的保存活性.
科学领域:
- 微生物学
- 进化生物学
- 生物技术
背景情况:
- 口腔微生物组的稳定性允许微生物相互作用的进化分析.
- 抗菌 (AMP) 或细菌素对于物种间的竞争至关重要.
- 牙科微积分保存了古老的口腔生物膜, 用于深入的进化研究.
研究的目的:
- 研究古老和现代口腔生物膜中AMP的多样性和进化轨迹.
- 确定保存的AMP家族并阐明它们在10万年内的生态功能.
- 为了利用进化的洞察力发现天然产品和下一代疗法.
主要方法:
- 古代和现代牙科微积分的基因组测序.
- 已识别的抗菌的结构建模.
- 对功能和抗菌活性进行实验验证.
- 遗传学分析可以重建进化历史.
主要成果:
- 鉴定出一种由Actinomyces衍生而来的防类,称为activensins,存在于所有采样时间段.
- 在古代 (古) 和现代活性植物之间展示了共同的祖先和适应性多样化.
- 在进化过程中提供了积极选择的证据,并保持了活性的抗菌活性.
结论:
- 口腔微生物群是发现具有治疗潜力的新型天然产品的丰富储存库.
- 对AMP功能的进化见解可以指导下一代治疗方法的开发,以对抗抗菌素耐药性.
- 该平台有效地将古代生物分子与生物技术应用联系起来.
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