通过通过CCL2/CCR2信号,PLAGL2通过招募瘤相关的巨细胞来促进HCC的进展
Yumeng Shen1, Dongqing Zhai1,2,3, Weijun Zhao1,2,3
1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
British journal of pharmacology
|December 17, 2025
概括
该研究显示,PLAGL2通过通过CCL2-CCR2通路促进瘤相关巨细胞 (TAM) 招募和M2极化,推动肝细胞癌 (HCC) 的进展,这表明PLAGL2是HCC的潜在治疗标.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 瘤相关巨细胞 (TAMs) 是肝细胞癌 (HCC) 进展的关键驱动因素.
- PLAGL2被确定为HCC的驱动因素,但其在调节免疫抑制瘤微环境中的作用尚不清楚.
研究的目的:
- 阐明PLAGL2调节HCC中TAMs的分子机制.
- 研究PLAGL2在控制HCC的免疫抑制微环境中的作用.
主要方法:
- 使用了小鼠正体肝癌,皮下瘤和体外共同培养模型.
- 采用单细胞测序和流细胞测量来分析免疫细胞亚群.
- 通过PLAGL2.2研究了CCL2的转录调节.
主要成果:
- PLAGL2表达与增加的TAM招募,M2极化和更差的HCC预后相关.
- PLAGL2促进巨细胞迁移和M2极化,招募CCR2+巨细胞.
- PLAGL2直接调节CCL2转录,通过CCL2-CCR2轴驱动HCC的进展.
结论:
- 通过CCL2-CCR2轴调节TAM化学反应和M2极化,PLAGL2促进了一个免疫抑制的HCC微环境.
- PLAGL2作为CCL2.2的一个新型转录因子.
- PLAGL2代表了HCC治疗的潜在治疗标.
更多相关视频
08:50In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines
Published on: April 18, 2025
849
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
8.0K
相关概念视频
02:30Metastasis
6.3K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.3K
01:07MAPK Signaling Cascades
7.8K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
7.8K
01:24Liver Regeneration
4.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.2K