脑雾与长期的Covid和化疗:系统性审查和元分析
Jack Christopher Wilson1, Kathy Y Liu2, Emma Mittelman3
1Psychiatry, UCL, London, UK jack.wilson.13@ucl.ac.uk.
BMJ mental health
|December 17, 2025
概括
长期COVID和化疗患者的脑雾涉及认知问题,疲劳和情绪问题. 需要标准化的评估工具,以便在这些群体之间进行更好的比较和理解.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 脑雾,以认知,功能和情感症状为特征,是长期COVID和化疗恢复中报告的一个问题.
- 了解这些不同人群中脑雾的具体特征和评估方法对于有效管理至关重要.
研究的目的:
- 系统地审查和分析经历长期COVID和化疗后患者脑雾的认知,功能和情感特征.
- 评估在这些人群中调查脑雾的研究中使用的评估方法.
主要方法:
- 一项系统性审查和对2024年3月之前发表的同行评审研究的元分析,包括2025年5月的更新.
- 在PubMed,Embase和Web of Science进行了搜索,寻找在COVID-19或化疗后患有脑雾的成年人的研究.
- 对符合条件的长期COVID研究进行了随机效应元分析,并使用NIH工具进行了偏差评估.
主要成果:
- 65项研究符合纳入标准,其中40项是长期COVID,25项是化疗.
- 对九项长期COVID研究的元分析显示,与对照人群相比,脑雾患者的认知表现显著下降,疲劳更高,抑郁症状增加.
- 发现了很高的异质性 (I2>70%),并且没有任何化疗研究适合进行元分析,排除了群体之间的直接比较.
结论:
- 长期COVID和化疗中的大脑雾与认知投诉,疲劳和情绪障碍有关.
- 评估工具的显著差异凸显了对标准化的需要.
- 在未来的研究中采用一致的定义和工具对于改善不同患者群体的可比性和临床理解至关重要.
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