生物启发的低摩擦和高稳定性水友涂层用于囊内镜表面
Chuangxin Huang1,2, Xin Liu1, Qi Chen1
1Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341119, China.
Langmuir : the ACS journal of surfaces and colloids
|December 17, 2025
概括
使用聚多巴胺和兹维特聚合物的新生物灵感复合涂层显著减少囊内镜 (CE) 上的摩擦和生物污染. 这种表面修改提高了CE的安全性和性能,以获得更好的胃肠道成像.
科学领域:
- 生物材料科学 生物材料科学
- 表面化学 表面化学
- 胃肠病学设备 胃肠病学设备
背景情况:
- 聚碳酸 (PC) 囊内镜 (CE) 遭受高摩擦,生物污染 (蛋白质吸附,细菌粘附) 和不稳定的表面变化,危及临床使用和患者安全.
- 现有的表面修饰策略往往缺乏强大的粘附性和长期稳定性,这限制了它们在生物医学应用中的有效性.
研究的目的:
- 为基于PC的囊内镜 (CE) 开发一种强大的,生物灵感的复合涂层,以克服摩擦和生物污染的限制.
- 通过先进的表面改造来提高CE的安全性和功能.
主要方法:
- 使用一阶段的氧化共沉积方法,通过聚多巴胺 (PDA) 中间层将聚甲基酸 (PSBMA) 移植到PC基板上,从而创建PC-PDA和PSB复合涂层.
- 描述技术包括XPS,SEM和AFM,以验证涂层沉积和形态.
- 通过接触角度测量,摩擦系数测试,蛋白质吸附试验 (BSA/BFG),稳定性测试 (pH 1.5 PBS) 和体外细胞相容性评估 (CCK-8,活/死染) 来评估性能.
主要成果:
- PC-PDA&PSB涂层具有较低的水接触角度 (14.3±3.1°) 和极低的摩擦系数 (<0.05).
- 该涂层实现了80%以上的蛋白质吸附抑制,并在酸性条件下表现出持续的稳定性 (pH 1.5 PBS 14天).
- 在体外研究证实了非细胞毒性,细胞活力超过80%,符合ISO 10993-5标准.
结论:
- 生物灵感的PDA和zwitterionic聚合物复合涂层有效地提高了PC基板的滑性和防性质.
- 这种可扩展的表面修改策略克服了与单独zwitterionic聚合物相关的粘附问题,提高了CE的安全性和性能.
- 开发的涂层显示出在囊内镜和其他需要增强滑动和防腐表面的生物医学设备中应用的巨大潜力.
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